Quantifying the cortical contribution to the NIRS signal using simultaneous NIRS-BOLD measurements

Louis Gagnon; Meryem A. Yücel; Mathieu Dehaes; Robert J. Cooper; Katherine L. Perdue; Juliette Selb; David A. Boas

doi:10.1117/12.909629

29 February 2012 Quantifying the cortical contribution to the NIRS signal using simultaneous NIRS-BOLD measurements

Louis Gagnon, Meryem A. Yücel, Mathieu Dehaes, Robert J. Cooper, Katherine L. Perdue, Juliette Selb, David A. Boas

Proceedings Volume 8216, Multimodal Biomedical Imaging VII; 82160F (2012) https://doi.org/10.1117/12.909629
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Near-Infrared Spectroscopy (NIRS) measures the functional hemodynamic response occuring at the surface of the cortex. Large pial veins are located above the surface of the cerebral cortex. Following activation, these veins exhibit oxygenation changes but their volume likely stays constant. The back-reflection geometry of the NIRS measurement renders the signal very sensitive to these superficial pial veins. As such, the measured NIRS signal contains contributions from both the cortical region as well as the pial vasculature. In this work, the cortical contribution to the NIRS signal was investigated using (1) Monte Carlo simulations over a realistic geometry constructed from anatomical and vascular MRI and (2) multimodal NIRS-BOLD recordings during motor stimulation. A good agreement was found between the simulations and the modeling analysis of in vivo measurements. Our results suggest that the cortical contribution to the deoxyhemoglobin signal change (ΔHbR) is equal to 16-22% of the cortical contribution to the total hemoglobin signal change (ΔHbT). Similarly, the cortical contribution of the oxyhemoglobin signal change (ΔHbO) is equal to 73-79% of the cortical contribution to the ΔHbT signal. These results suggest that ΔHbT is far less sensitive to pial vein contamination and therefore, it is likely that the ΔHbT signal provides better spatial specificity and should be used instead of ΔHbO or ΔHbR to map cerebral activity with NIRS. While different stimuli will result in different pial vein contributions, our finger tapping results do reveal the importance of considering the pial contribution.

Citation Download Citation

Louis Gagnon, Meryem A. Yücel, Mathieu Dehaes, Robert J. Cooper, Katherine L. Perdue, Juliette Selb, and David A. Boas "Quantifying the cortical contribution to the NIRS signal using simultaneous NIRS-BOLD measurements", Proc. SPIE 8216, Multimodal Biomedical Imaging VII, 82160F (29 February 2012); https://doi.org/10.1117/12.909629

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
12 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Near infrared spectroscopy

Veins

Monte Carlo methods

Brain

In vivo imaging

Tissue optics

Functional magnetic resonance imaging

Show All Keywords

Keywords/Phrases

Search In:

Publication Years