Multifunctional gold nanorods for image-guided surgery and photothermal therapy

Clement Barriere; Ji Qi; P. Beatriz Garcia-Allende; Richard Newton; Daniel S. Elson

doi:10.1117/12.908253

6 February 2012 Multifunctional gold nanorods for image-guided surgery and photothermal therapy

Clement Barriere, Ji Qi, P. Beatriz Garcia-Allende, Richard Newton, Daniel S. Elson

Proceedings Volume 8234, Plasmonics in Biology and Medicine IX; 82340Z (2012) https://doi.org/10.1117/12.908253
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Nanoparticles are viewed as a promising tool for numerous medical applications, for instance imaging and photothermal therapy (PTT) has been proposed using gold nanorods. We are developing multi-functional gold nanorods (m-GNRs) which have potential for image guided endoscopic surgery of tumour tissue with a modified laparoscope system. A new synthesis method potentially allows any useful acid functionalised molecules to be bonded at the surface. We have created fluorescent m-GNRs which can be used for therapy as they absorb light in the infrared, which may penetrate deep into the tissue and produce localised heating. We have performed a tissue based experiment to demonstrate the feasibility of fluorescence guided PTT using m- GNRs. Ex vivo tests were performed using sheep heart. This measurement, correlated with the fluorescence signal of the m-GNRs measured by the laparoscope allows the clear discrimination of the artery system containing m-GNRs. A laser diode was used to heat the m-GNRs and a thermal camera was able to record the heat distribution. These images were compared to the fluorescence images for validation.

Citation Download Citation

Clement Barriere, Ji Qi, P. Beatriz Garcia-Allende, Richard Newton, and Daniel S. Elson "Multifunctional gold nanorods for image-guided surgery and photothermal therapy", Proc. SPIE 8234, Plasmonics in Biology and Medicine IX, 82340Z (6 February 2012); https://doi.org/10.1117/12.908253

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available