Changes of MR and DTI appearance in early human brain development

Cassian Marc; Clement Vachet; Guido Gerig; Joseph Blocher; John Gilmore; Martin Styner

doi:10.1117/12.844912

12 March 2010 Changes of MR and DTI appearance in early human brain development

Cassian Marc, Clement Vachet, Guido Gerig, Joseph Blocher, John Gilmore, Martin Styner

Proceedings Volume 7623, Medical Imaging 2010: Image Processing; 762324 (2010) https://doi.org/10.1117/12.844912
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

Understanding myelination in early brain development is of clinical importance, as many neurological disorders have their origin in early cerebral organization and maturation. The goal of this work is to study a large neonate database acquired with standard MR imagery to illuminate effects of early development in MRI. 90 neonates were selected from a study of healthy brain development. Subjects were imaged via MRI postnatally. MR acquisition included high-resolution structural and diffusion tensor images. Unbiased atlases for structural and DTI data were generated and co-registered into a single coordinate frame for voxel-wise comparison of MR and DTI appearance across time. All original datasets were mapped into this frame and structural image data was additionally intensity normalized. In addition, myelinated white matter probabilistic segmentations from our neonate tissue segmentation were mapped into the same space to study how our segmentation results were affected by the changing intensity characteristics in early development Linear regression maps and p-value maps were computed and visualized. The resulting visualization of voxelswise corresponding maps of all MR and DTI properties captures early development information in MR imagery. Surprisingly, we encountered regions of seemingly decreased myelinated WM probability over time even though we expected a confident increase for all of the brain. The intensity changes in the MR images in those regions help explain this counterintuitive result. The regressional results indicate that this is an effect of intensity changes due not solely to myelination processes but also likely brain dehydration processes in early postnatal development.

Citation Download Citation

Cassian Marc, Clement Vachet, Guido Gerig, Joseph Blocher, John Gilmore, and Martin Styner "Changes of MR and DTI appearance in early human brain development", Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 762324 (12 March 2010); https://doi.org/10.1117/12.844912

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