Spatially offset Raman spectroscopy and diffuse Raman tomography: subsurface spectroscopy and imaging in animal tissue and other scattering media

Michael D. Morris

doi:10.1117/12.786446

8 February 2008 Spatially offset Raman spectroscopy and diffuse Raman tomography: subsurface spectroscopy and imaging in animal tissue and other scattering media

Michael D. Morris

Author Affiliations +

Proceedings Volume 6853, Biomedical Optical Spectroscopy; 68530I (2008) https://doi.org/10.1117/12.786446
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

It has been less than three years since the beginnings of systematic development of fiber optic Raman illumination/collection systems for operation in the presence of extensive photon diffusion. These fiber optic probes depend on spatial separation of illumination and collection regions to deep Raman spectroscopy and imaging in highly scattering media. Both backscattering and transmission systems have been described in the literature. They are closely related to probes used for fluorescence imaging and tomography in turbid media, but in most there are modifications to allow distributed laser illumination to provide high absolute power without thermal damage. We review the history of the spatially resolved techniques, discuss data reduction issues and current probe designs and survey current applications to human and animal tissue.

Citation Download Citation

Michael D. Morris "Spatially offset Raman spectroscopy and diffuse Raman tomography: subsurface spectroscopy and imaging in animal tissue and other scattering media", Proc. SPIE 6853, Biomedical Optical Spectroscopy, 68530I (8 February 2008); https://doi.org/10.1117/12.786446

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