High-speed imaging of retinal pathology using ultrahigh-resolution spectral/Fourier domain optical coherence tomography in the ophthalmology clinic

Tony Ko; Maciej Wojtkowski; Vivek Srinivasan; Jay Duker; Joel S. Schuman; James G. Fujimoto

doi:10.1117/12.592683

13 April 2005 High-speed imaging of retinal pathology using ultrahigh-resolution spectral/Fourier domain optical coherence tomography in the ophthalmology clinic

Tony Ko, Maciej Wojtkowski, Vivek Srinivasan, Jay Duker, Joel S. Schuman, James G. Fujimoto

Author Affiliations +

Proceedings Volume 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX; (2005) https://doi.org/10.1117/12.592683
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

An ultrahigh resolution spectral domain optical coherence tomography (OCT) system capable of performing high speed imaging in the ophthalmology clinic has been developed. An OCT system using spectral/Fourier domain enables high speed imaging rates of up to 25,000 axial scans (A-scan) per second. Using a low threshold femtosecond Ti:sapphire laser light source, which can generate bandwidths of ~125 nm at 800 nm, cross-sectional imaging of the retina with ~3 μm axial resolution is possible. High speed imaging has been performed in the ophthalmology clinic on patients with various retinal pathologies using the ultrahigh resolution spectral domain OCT system. High pixel density OCT images containing 1024 pixels and 2048 transverse lines (A-scans) can be acquired in 0.08 seconds, which represents a ~100 fold improvement in imaging speed over previously reported time-domain ultrahigh resolution OCT systems. High speed imaging also enables three dimensional scanning and mapping of intraretinal architectural morphology with unprecedented resolution. High speed ultrahigh resolution OCT is a powerful tool for visualizing retinal pathologies, especially those involving the details of the photoreceptor segments; it will enable three-dimensional retinal imaging and the rendering of image information from volumetric data, and it has the potential to improve the early diagnosis of retinal diseases.

Citation Download Citation

Tony Ko, Maciej Wojtkowski, Vivek Srinivasan, Jay Duker, Joel S. Schuman, and James G. Fujimoto "High-speed imaging of retinal pathology using ultrahigh-resolution spectral/Fourier domain optical coherence tomography in the ophthalmology clinic", Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); https://doi.org/10.1117/12.592683

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available