Enhancing the photoluminescence of peptide-coated nanocrystals

James M. Tsay; Soeren Doose; Fabien Pinaud; Shimon Weiss

doi:10.1117/12.589458

28 April 2005 Enhancing the photoluminescence of peptide-coated nanocrystals

James M. Tsay, Soeren Doose, Fabien Pinaud, Shimon Weiss

Proceedings Volume 5705, Nanobiophotonics and Biomedical Applications II; (2005) https://doi.org/10.1117/12.589458
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Colloidal NCs consist of an inorganic particle and an organic coating that determines their solubility, functionality, and influences their photophysics. In order for these NCs to be biocompatible, they must be water-soluble, nontoxic to the cell, and offer conjugation chemistries for attaching recognition molecules to their surfaces. In addition they should efficiently target to biomolecules of interest, be chemically stable, and preserve their high photostability. The requirements for their application in single-molecule biological studies are even more stringent: fluorescent NCs should be monodisperse, have relatively small size (to limit steric hindrance), reduced blinking, large saturation intensity, and high quantum yield (QY).

Citation Download Citation

James M. Tsay, Soeren Doose, Fabien Pinaud, and Shimon Weiss "Enhancing the photoluminescence of peptide-coated nanocrystals", Proc. SPIE 5705, Nanobiophotonics and Biomedical Applications II, (28 April 2005); https://doi.org/10.1117/12.589458

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