Complexation of dextran and glucose with thiolate boronic acid capped on nanoparticle

Jian Zhang; Chris D. Geddes; Joseph R. Lakowicz

doi:10.1117/12.530059

1 July 2004 Complexation of dextran and glucose with thiolate boronic acid capped on nanoparticle

Jian Zhang, Chris D. Geddes, Joseph R. Lakowicz

Proceedings Volume 5321, Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies; (2004) https://doi.org/10.1117/12.530059
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Tiopronin-monolayer protected silver nanoparticles (average diameter = 5 nm) were partially replaced by thiolate boronic acid via ligand exchange. The uncapped boronic acids could be coupled with both a polysaccharide (Dextran) and a monoaccharide (glucose). Boronic acids capped on the particle were coupled selectively only by Dextran. With the decrease of charge on particle surface at pH = 5, boronic acids capped on the particle could be coupled with glucose. The particles were observed to aggregate along the Dextran chain, resulting in an absorbance decrease of the transverse plasmon at 397 nm and simultaneous rising of longitudinal plasmon at 640 nm. The aggregation increased with the concentration of Dextran. Luminescence intensity of phenyl boronic acid was enhanced by an upward deviation from a line with the concentration of Dextran in solution but the decay time was decreased, principally by the aggregation of the metallic cores.

Citation Download Citation

Jian Zhang, Chris D. Geddes, and Joseph R. Lakowicz "Complexation of dextran and glucose with thiolate boronic acid capped on nanoparticle", Proc. SPIE 5321, Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies, (1 July 2004); https://doi.org/10.1117/12.530059

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