Progress in the noninvasive in-vivo tissue-modulated Raman spectroscopy of human blood

Joseph Chaiken; William F. Finney; Xiaoke Yang; Paul E. Knudson; Karen P. Peterson; Charles M. Peterson; Ruth S. Weinstock; Douglas Hagrman

doi:10.1117/12.427936

4 June 2001 Progress in the noninvasive in-vivo tissue-modulated Raman spectroscopy of human blood

Joseph Chaiken, William F. Finney, Xiaoke Yang, Paul E. Knudson, Karen P. Peterson, Charles M. Peterson, Ruth S. Weinstock, Douglas Hagrman

Author Affiliations +

Proceedings Volume 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III; (2001) https://doi.org/10.1117/12.427936
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

We have recently presented the first Raman spectra of in vivo human blood. A brief review of how to obtain such spectra and normalize them to the appropriate blood volume is given showing how to produce spectra that can be used for noninvasive quantitative analysis of blood in vivo. New clinical data from individuals and groups completely reproduce and extend all the earlier results. These new data reveal how certain small differences between individuals result in some variability in their noninvasive quantitation. We show the origin of this variability and how to obtain quantitative corrections based entirely on the individual measurement and tabulated data.

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Joseph Chaiken, William F. Finney, Xiaoke Yang, Paul E. Knudson, Karen P. Peterson, Charles M. Peterson, Ruth S. Weinstock, and Douglas Hagrman "Progress in the noninvasive in-vivo tissue-modulated Raman spectroscopy of human blood", Proc. SPIE 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, (4 June 2001); https://doi.org/10.1117/12.427936

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