Intraoperative spectroscopic-guided brain tumor resection: reduction of blood contamination effects on tissue optical spectra

Wei-Chiang Lin; Anita Mahadevan-Jansen; E. Duco Jansen

doi:10.1117/12.427932

4 June 2001 Intraoperative spectroscopic-guided brain tumor resection: reduction of blood contamination effects on tissue optical spectra

Wei-Chiang Lin, Anita Mahadevan-Jansen, E. Duco Jansen

Author Affiliations +

Proceedings Volume 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III; (2001) https://doi.org/10.1117/12.427932
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

An optical spectroscopy-based system for intraoperative guidance of brain tumor resection is currently under development at Vanderbilt University and Vanderbilt University Medical Center. The effectiveness of brain tumor margin detection, especially the infiltrating type, using combined in vivo autofluorescence and diffuse reflectance spectroscopy was successfully demonstrated in a preliminary clinical trial (on a total of 26 brain tumor patients). In this trial, a two-step empirical discrimination algorithm based on autofluorescence and diffuse reflectance intensity at 460 nm and 625 nm yielded 100% sensitivity and 76% specificity in differentiating infiltrating tumor margins from normal brain tissues.

Citation Download Citation

Wei-Chiang Lin, Anita Mahadevan-Jansen, and E. Duco Jansen "Intraoperative spectroscopic-guided brain tumor resection: reduction of blood contamination effects on tissue optical spectra", Proc. SPIE 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, (4 June 2001); https://doi.org/10.1117/12.427932

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