Prominent microscopic effects in microfabricated fluidic analysis systems

James P. Brody; Andrew Evan Kamholz; Paul Yager

doi:10.1117/12.269960

31 March 1997 Prominent microscopic effects in microfabricated fluidic analysis systems

James P. Brody, Andrew Evan Kamholz, Paul Yager

Proceedings Volume 2978, Micro- and Nanofabricated Electro-Optical Mechanical Systems for Biomedical and Environmental Applications; (1997) https://doi.org/10.1117/12.269960
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

Microfabricated fluidic systems allow complex chemical analyses to be performed on sub-nanoliter volumes of sample. Compared to macroscopic systems, these devices offer many advantages, including the promise of performing some analytical functions more rapidly and on smaller samples. However, miniaturization of analytic instruments is not simply a matter of reducing their size. At small scales, different effects become more prominent, rendering some processes inefficient and others useless. The small scales also permit the creation of novel devices, such as the H- filter, which we are using to extract analytes from whole blood. Fluid flow in microfluidic systems is entirely dominated by viscous forces, making diffusion the sole mechanism of mixing. In addition, a larger fraction of molecules are lost to surface adsorption as devices shrink. This paper examines some of the issues involved in device miniaturization, specifically those phenomena that become increasingly dominant.

Citation Download Citation

James P. Brody, Andrew Evan Kamholz, and Paul Yager "Prominent microscopic effects in microfabricated fluidic analysis systems", Proc. SPIE 2978, Micro- and Nanofabricated Electro-Optical Mechanical Systems for Biomedical and Environmental Applications, (31 March 1997); https://doi.org/10.1117/12.269960

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