Comparison of multi-fiber reproducibility of PAS-MRI and Q-ball with empirical multiple b-value HARDI

Vishwesh Nath; Kurt G. Schilling; Justin A. Blaber; Zhaohua Ding; Adam W. Anderson; Bennett A. Landman

doi:10.1117/12.2254736

24 February 2017 Comparison of multi-fiber reproducibility of PAS-MRI and Q-ball with empirical multiple b-value HARDI

Vishwesh Nath, Kurt G. Schilling, Justin A. Blaber, Zhaohua Ding, Adam W. Anderson, Bennett A. Landman

Proceedings Volume 10133, Medical Imaging 2017: Image Processing; 101330L (2017) https://doi.org/10.1117/12.2254736
Event: SPIE Medical Imaging, 2017, Orlando, Florida, United States

Abstract

Crossing fibers are prevalent in human brains and a subject of intense interest for neuroscience. Diffusion tensor imaging (DTI) can resolve tissue orientation but is blind to crossing fibers. Many advanced diffusion-weighted magnetic resolution imaging (MRI) approaches have been presented to extract crossing-fibers from high angular resolution diffusion imaging (HARDI), but the relative sensitivity and specificity of approaches remains unclear. Here, we examine two leading approaches (PAS and q-ball) in the context of a large-scale, single subject reproducibility study. A single healthy individual was scanned 11 times with 96 diffusion weighted directions and 10 reference volumes for each of five b-values (1000, 1500, 2000, 2500, 3000 s/mm2) for a total of 5830 volumes (over the course of three sessions). We examined the reproducibility of the number of fibers per voxel, volume fraction, and crossing-fiber angles. For each method, we determined the minimum resolvable angle for each acquisition. Reproducibility of fiber counts per voxel was generally high (~80% consensus for PAS and ~70% for q-ball), but there was substantial bias between individual repetitions and model estimated with all data (~10% lower consensus for PAS and ~15% lower for q-ball). Both PAS and q-ball predominantly discovered fibers crossing at near 90 degrees, but reproducibility was higher for PAS across most measures. Within voxels with low anisotropy, q-ball finds more intra-voxel structure; meanwhile, PAS resolves multiple fibers at greater than 75 degrees for more voxels. These results can inform researchers when deciding between HARDI approaches or interpreting findings across studies.

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Vishwesh Nath, Kurt G. Schilling, Justin A. Blaber, Zhaohua Ding, Adam W. Anderson, and Bennett A. Landman "Comparison of multi-fiber reproducibility of PAS-MRI and Q-ball with empirical multiple b-value HARDI", Proc. SPIE 10133, Medical Imaging 2017: Image Processing, 101330L (24 February 2017); https://doi.org/10.1117/12.2254736

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