Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes

Chen Wu; Zhaolong Han; Shang Wang; Jiasong Li; Manmohan Singh; Chih-hao Liu; Salavat Aglyamov; Stanislav Emelianov; Fabrice Manns; Kirill V. Larin

doi:10.1117/12.2079532

12 March 2015 Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes

Chen Wu, Zhaolong Han, Shang Wang, Jiasong Li, Manmohan Singh, Chih-hao Liu, Salavat Aglyamov, Stanislav Emelianov, Fabrice Manns, Kirill V. Larin

Author Affiliations +

Proceedings Volume 9307, Ophthalmic Technologies XXV; 930716 (2015) https://doi.org/10.1117/12.2079532
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

In this study, we utilize a confocal ultrasound and phase-sensitive optical coherence elastography (OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in intact rabbit eyes in situ. Lowamplitude elastic deformations, induced on the surface of the lens by localized acoustic radiation force, were measured using phase-sensitive OCT. The results demonstrate that the displacements induced in young rabbit lenses are significantly larger than those in the mature lenses. Temporal analyses of the elastic waves are also demonstrated significant difference between young and old lenses, indicating that the stiffness of lens increases with the age. These results demonstrate possibility of OCE for completely noninvasive analysis and quantification of lens biomechanical properties, which could be used in many clinical and basic science applications such as surgeries and studies on lens physiology and function.

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Chen Wu, Zhaolong Han, Shang Wang, Jiasong Li, Manmohan Singh, Chih-hao Liu, Salavat Aglyamov, Stanislav Emelianov, Fabrice Manns, and Kirill V. Larin "Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes", Proc. SPIE 9307, Ophthalmic Technologies XXV, 930716 (12 March 2015); https://doi.org/10.1117/12.2079532

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