Near-infrared light-triggered dissociation of block copolymer micelles for controlled drug release

Jie Cao; Shanshan Huang; Yuqi Chen; Siwen Li; Samuel Achilefu; Zhiyu Qian; Yueqing Gu

doi:10.1117/12.2003247

21 February 2013 Near-infrared light-triggered dissociation of block copolymer micelles for controlled drug release

Jie Cao, Shanshan Huang, Yuqi Chen, Siwen Li, Samuel Achilefu, Zhiyu Qian, Yueqing Gu

Proceedings Volume 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V; 859606 (2013) https://doi.org/10.1117/12.2003247
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

In this manuscript, a new near-infrared (NIR) light-breakable amphiphilic block copolymer containing light-sensitive triggering group on the hydrophobic block was developed. By encapsulating NIR dye cypate inside micelles of poly (N-succinyl-N'-4- (2-nitrobenzyloxy)-succinyl chitosan) and exposing the micellar solution to 765.9 nm light, the photo-cleavage reaction was activated and leading to the dissociation of micelles and release of co-loaded hydrophobic species. The UV-vis absorption spectra, fourier transform infrared (FTIR) spectra and ¹H nuclear magnetic resonance (¹H NMR) spectra of micelles were characterized. Triggered burst release of the payload upon NIR irradiation and subsequent degradation of the micelles were observed by transmission electron microscopy (TEM). This system represents a general and efficient method to circumvent the need for UV or visible light excitation that is a common drawback for light-responsive polymeric systems developed for potential biomedical applications.

Citation Download Citation

Jie Cao, Shanshan Huang, Yuqi Chen, Siwen Li, Samuel Achilefu, Zhiyu Qian, and Yueqing Gu "Near-infrared light-triggered dissociation of block copolymer micelles for controlled drug release", Proc. SPIE 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, 859606 (21 February 2013); https://doi.org/10.1117/12.2003247

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Near infrared

Transmission electron microscopy

FT-IR spectroscopy

Luminescence

Ultraviolet radiation

Biomedical optics

Polymers

Show All Keywords

Keywords/Phrases

Search In:

Publication Years