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The role of CD98 in astrocytic neoplasms

  • 2001 Human Cell Society Award
  • Published:
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Abstract

The high expression of CD98 was reported in some normal tissues, including blood brain barrier, activated lymphocytes, the basal layer of skin, proximal tubles of kidney, placenta, testis and a wide variety of tumors. The CD98 complex consists of an 80–85kD heavy chain (4F2hc/FRP-1) and a 40–45kD light chain. CD98hc, 4F2hc, and FRP-1 are the same glycosylated protein each other and define antigenicity of CD98. LAT1, the sodium-independent L-type amino acid transporter 1, has been identified as a light chain of the CD98 heterodimer from C6 glioma cells. LAT1 also corresponds to TA1, an oncofetal antigen that is expressed primarily in fetal tissues and cancer cells such as glioma cells. Increased LAT1 expression was found in various malignancies including human gliomas. Several studies implicated the important role of LAT1 and 4F2hc in malignant transformation and carcinogenesis. The LAT1-CD98 pathway may represent a unique therapeutic target for cancer intervention.

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Authors and Affiliations

  1. Department of Neurosurgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Saitama, Japan

    Hiroshi Nawashiro, Naoki Otani, Shinji Fukui, Namiko Nomura, Akiko Yano & Katsuji Shima

  2. Department of Microbiology, National Defense Medical Colleges, Japan

    Nariyoshi Shinomiya

  3. Department of Pharmacology and Toxicology, Kyorin University, School of Medicine, Japan

    Hirotaka Matsuo & Yoshikatsu Kanai

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  1. Hiroshi Nawashiro
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  2. Naoki Otani
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Nawashiro, H., Otani, N., Shinomiya, N. et al. The role of CD98 in astrocytic neoplasms. Hum Cell 15, 25–31 (2002). https://doi.org/10.1111/j.1749-0774.2002.tb00096.x

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  • DOI: https://doi.org/10.1111/j.1749-0774.2002.tb00096.x

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