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Brief report: Risk factors for pneumococcal vaccine refusal in adults

A case-control study

  • Original Article
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Abstract

BACKGROUND: Invasive pneumococcal disease is a significant cause of morbidity and mortality in the United States. Despite availability of an effective vaccine, many patients refuse vaccination.

OBJECTIVE: To investigate patient characteristics and features of the patient-provider relationship associated with pneumococcal vaccine refusal.

DESIGN: Case-control study using chart review.

PATIENTS: Five hundred adults from the medical clinics of a 1,000-bed inner-city teaching hospital.

MEASUREMENTS AND MAIN RESULTS: Independent risk factors for pneumococcal vaccine refusal included patient-provider gender discordance (odds ratio (OR)=2.09, 95% confidence interval (CI) 1.07 to 4.09); a visit to a not-usual provider at the time of vaccine offering (OR=2.26, 95% CI 1.13 to 4.49); never having received influenza vacination (OR=7.44, 95% CI 3.76 to 14.76); prior pneumococcal vaccine refusals (OR=3.45, 95% CI 1.60 to 7.43); and a history of ever having refused health maintenance tests (OR=2.86, 95% CI 1.40 to 5.84).

CONCLUSIONS: We have identified both patient factors and factors related to the patient-provider relationship that are risk factors for pneumococcal vaccine refusal. By identifying patients at risk for pneumococcal vaccine refusal, efforts to increase vaccination rates can be better targeted.

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Correspondence to Lesley S. Miller MD.

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The authors of this manuscript report no conflicts of interest.

This work was supported in part by a grant from the National Vaccine Program and the CDC Emerging Infections Program.

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Miller, L.S., Kourbatova, E.V., Goodman, S. et al. Brief report: Risk factors for pneumococcal vaccine refusal in adults. J GEN INTERN MED 20, 650–652 (2005). https://doi.org/10.1111/j.1525-1497.2005.0118.x

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  • DOI: https://doi.org/10.1111/j.1525-1497.2005.0118.x

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