Original ArticleThe Introduction of Human Heme Oxygenase-1 and Soluble Tumor Necrosis Factor-α Receptor Type I With Human IgG1 Fc in Porcine Islets Prolongs Islet Xenograft Survival in Humanized Mice
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basic (laboratory) research / science
islet transplantation
xenotransplantation
cytokines / cytokine receptors
innate immunity
rejection
cell death: apoptosis
xenoantigen
Abbreviations
Ad-
adenovirus containing
AUC
area under the curve
CHX
cycloheximide
ELISA
enzyme-linked immunosorbent assay
ELISPOT
Enzyme-Linked ImmunoSpot assay
GFP
green fluorescent protein
HO-1
heme oxygenase-1
HRP
horseradish peroxidase
IFN
interferon-γ
IP-10
interferon-γ–induced protein 10
IPGTT
intraperitoneal glucose tolerance test
LPS
lipopolysaccharide
MOI
multiplicity of infection
NSG
NOD-scid IL-2Rγnull
RT-PCR
reverse transcriptase–polymerase chain reaction
SEM
standard error of the mean;
sTNF-αR
soluble tumor necrosis factor-α receptor type I
sTNF-αR-Fc
soluble tumor necrosis factor-α receptor type I with human IgG1 Fc
TNF-α
tumor necrosis factor-α;
TUNEL
terminal deoxynucleotidyl transferase dUTP nick end labeling
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Copyright © 2016 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.