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Diverse functions of the p75 neurotrophin receptor

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Abstract

The pan-neurotrophin receptor p75NTR belongs to a large family of receptors, which includes tumor necrosis factor receptors, Fas and approximately 25 other members. The p75NTR is the first receptor to be cloned molecularly. Recent years have seen the emergence of a consensus regarding the signaling pathways activated by p75NTR and its potential biological function, although receptor characterization had not been targeted for some years. We now know that p75NTR has surprisingly diverse effects, ranging from cell death to regulation of axon elongation. This diversity can be explained by the complex formation of p75NTR with other receptors and multiple signaling molecules that interact with the intracellular domain of p75NTR.

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Authors and Affiliations

  1. Department of Neurobiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, 260-8670, Chiba, Japan

    Toshihide Yamashita, Masashi Fujitani, Katsuhiko Hata, Fumiaki Mimura & Satoru Yamagishi

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  1. Toshihide Yamashita
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  2. Masashi Fujitani
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  3. Katsuhiko Hata
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  4. Fumiaki Mimura
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  5. Satoru Yamagishi
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Correspondence to Toshihide Yamashita.

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Yamashita, T., Fujitani, M., Hata, K. et al. Diverse functions of the p75 neurotrophin receptor. Anato Sci Int 80, 37–41 (2005). https://doi.org/10.1111/j.1447-073x.2005.00095.x

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  • DOI: https://doi.org/10.1111/j.1447-073x.2005.00095.x

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