Review
Sulbactam-containing β-lactamase inhibitor combinations

https://doi.org/10.1111/j.1469-0691.2007.01847.xGet rights and content
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ABSTRACT

Sulbactam irreversibly inhibits the hydrolytic activity of β-lactamases. This compound is commercially available in combination with either ampicillin or cefoperazone. In each instance, the activity of the partner antibiotic against β-lactamase-producing bacteria is restored. One of the particular advantages of using sulbactam-containing combinations is that sulbactam itself has inherent activity against some Acinetobacter baumannii. Sulbactam combinations have not demonstrated strong selective pressures for extended-spectrum β-lactamase-producing Enterobacteriaceae and vancomycin-resistant enterococci. In contrast to clavulanate, sulbactam does not induce class I (Ampc) chromosomal β-lactamases in Enterobacteriaceae.

Keywords

Ampicillin
β-lactamase inhibitors
cefoperazone
sulbactam

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