Microviscoelastic Moduli of Biomimetic Cell Envelopes

Laurent Limozin, Alexander Roth, and Erich Sackmann

Phys. Rev. Lett. 95, 178101 – Published 17 October 2005

Abstract

Bioanalogue models of composite cell envelopes were designed by electrostatically driven self-assembly of actin shells inside giant vesicles. Viscoelastic relaxation moduli were measured between 0.03 and 20 s as a function of actin density by magnetic bead microrheometry. The shear relaxation spectra exhibited by the composite shells compare well with those of natural cell envelopes and bulk entangled actin networks. Absolute value of the shear modulus was measured for the first time by deformation field mapping. Shear and bending moduli agree well with values obtained by bead fluctuations analysis.

Received 7 February 2005

DOI:https://doi.org/10.1103/PhysRevLett.95.178101

Authors & Affiliations

Laurent Limozin^*, Alexander Roth, and Erich Sackmann

E22-Biophysik. Physik Department, Technical University of Munich, James Franck Strasse, D-85748 Garching, Germany

^*Electronic address: limozin@marseille.inserm.fr
^†Present address: Cellular Adhesion Group, CNRS FRE2059 Inserm U600, Hospital Sainte-Marguerite, BP 29, 13274 Marseille Cedex 09, France.

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Issue

Vol. 95, Iss. 17 — 21 October 2005

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