Diffusion dynamics, moments, and distribution of first-passage time on the protein-folding energy landscape, with applications to single molecules

Chi-Lun Lee; Chien-Ting Lin; George Stell; Jin Wang

doi:10.1103/PhysRevE.67.041905

Diffusion dynamics, moments, and distribution of first-passage time on the protein-folding energy landscape, with applications to single molecules

Chi-Lun Lee, Chien-Ting Lin, George Stell, and Jin Wang

Phys. Rev. E 67, 041905 – Published 17 April 2003

Abstract

We study the dynamics of protein folding via statistical energy-landscape theory. In particular, we concentrate on the local-connectivity case with the folding progress described by the fraction of native conformations. We found that the first passage-time (FPT) distribution undergoes a dynamic transition at a temperature below which the FPT distribution develops a power-law tail, a signature of the intermittent nonexponential kinetic phenomena for the folding dynamics. Possible applications to single-molecule dynamics experiments are discussed.

Received 2 September 2001

DOI:https://doi.org/10.1103/PhysRevE.67.041905

Authors & Affiliations

Chi-Lun Lee¹, Chien-Ting Lin², George Stell^2,*, and Jin Wang^3,2,4,5,*

¹Department of Physics, State University of New York at Stony Brook, Stony Brook, New York 11794
²Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794
³State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130021, People’s Republic of China
⁴Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542
⁵Global Strategic Analytics Unit, Citigroup, One Huntington Quadrangle, Suite 1N16, Melville, New York 11747

^*Author to whom correspondence should be addressed.

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Vol. 67, Iss. 4 — April 2003

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Physical Review E

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