Theory of Acoustic Raman Modes in Proteins

Timothy DeWolf and Reuven Gordon
Phys. Rev. Lett. 117, 138101 – Published 21 September 2016
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Abstract

We present a theoretical analysis that associates the resonances of extraordinary acoustic Raman (EAR) spectroscopy [Wheaton et al., Nat. Photonics 9, 68 (2015)] with the collective modes of proteins. The theory uses the anisotropic elastic network model to find the protein acoustic modes, and calculates Raman intensity by treating the protein as a polarizable ellipsoid. Reasonable agreement is found between EAR spectra and our theory. Protein acoustic modes have been extensively studied theoretically to assess the role they play in protein function; this result suggests EAR spectroscopy as a new experimental tool for studies of protein acoustic modes.

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  • Received 7 April 2016

DOI:https://doi.org/10.1103/PhysRevLett.117.138101

© 2016 American Physical Society

Physics Subject Headings (PhySH)

  1. Research Areas
  1. Physical Systems
Physics of Living Systems

Authors & Affiliations

Timothy DeWolf and Reuven Gordon*

  • Department of Electrical and Computer Engineering, University of Victoria, Victoria British Columbia V8P 5C2, Canada

  • *rgordon@uvic.ca

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Issue

Vol. 117, Iss. 13 — 23 September 2016

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