Phys. Rev. E 92, 042715 (2015) - Application of a free-energy-landscape approach to study tension-dependent bilayer tubulation mediated by curvature-inducing proteins

Application of a free-energy-landscape approach to study tension-dependent bilayer tubulation mediated by curvature-inducing proteins

Richard W. Tourdot, N. Ramakrishnan, Tobias Baumgart, and Ravi Radhakrishnan

Phys. Rev. E 92, 042715 – Published 29 October 2015; Erratum Phys. Rev. E 93, 059902 (2016)

Abstract

We investigate the phenomenon of protein-induced tubulation of lipid bilayer membranes within a continuum framework using Monte Carlo simulations coupled with the Widom insertion technique to compute excess chemical potentials. Tubular morphologies are spontaneously formed when the density and the curvature-field strength of the membrane-bound proteins exceed their respective thresholds and this transition is marked by a sharp drop in the excess chemical potential. We find that the planar to tubular transition can be described by a micellar model and that the corresponding free-energy barrier increases with an increase in the curvature-field strength (i.e., of protein-membrane interactions) and also with an increase in membrane tension.

Received 24 June 2015
Revised 18 August 2015

DOI:https://doi.org/10.1103/PhysRevE.92.042715

©2015 American Physical Society

Erratum

Erratum: Application of a free-energy-landscape approach to study tension-dependent bilayer tubulation mediated by curvature-inducing proteins [Phys. Rev. E 92, 042715 (2015)]

Richard W. Tourdot, N. Ramakrishnan, Tobias Baumgart, and Ravi Radhakrishnan

Phys. Rev. E 93, 059902 (2016)

Authors & Affiliations

Richard W. Tourdot^*

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

N. Ramakrishnan^†

Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

Tobias Baumgart^‡

Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

Ravi Radhakrishnan^§

Department of Chemical and Biomolecular Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

^*tourdot@seas.upenn.edu
^†ramn@seas.upenn.edu
^‡baumgart@sas.upenn.edu
^§rradhak@seas.upenn.edu

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Issue

Vol. 92, Iss. 4 — October 2015

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