Whole-Cell Recording in the Awake Brain
- 1Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34141, Republic of Korea;
- 2Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia 20147
- ↵3Correspondence: leedoyun{at}ibs.re.kr; leea{at}janelia.hhmi.org
Abstract
Intracellular recording is an essential technique for investigating cellular mechanisms underlying complex brain functions. Despite the high sensitivity of the technique to mechanical disturbances, intracellular recording has been applied to awake, behaving, and even freely moving, animals. Here we summarize recent advances in these methods and their application to the measurement and manipulation of membrane potential dynamics for understanding neuronal computations in behaving animals.
Footnotes
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From the Ion Channels collection, edited by Paul J. Kammermeier, Ian Duguid, and Stephan Brenowitz.
