Learning-induced enhancement of feedback inhibitory synaptic transmission
- Inbar Brosh and
- Edi Barkai,1
Abstract
Olfactory-discrimination learning results with a series of intrinsic and excitatory synaptic modifications in piriform cortex pyramidal neurons. Here we show that such learning results with long-lasting enhancement of inhibitory synaptic transmission onto proximal dendrites of these pyramidal neurons. Such enhancement is mediated by a strong hyperpolarizing shift in the reversal potential of fast inhibitory postsynaptic potentials (fIPSPs). Moreover, paired-pulse depression of these IPSPs, indicating enhanced GABA release, is also apparent after learning. We suggest that learning is accompanied by long-lasting enhancement of synaptic inhibition onto excitatory neurons, thus compensating for the increase of excitation in these neurons.
Footnotes
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↵1 Corresponding author.
E-mail ebarkai{at}research.haifa.ac.il; fax 972-8-8288108.
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.1430809.
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- Received March 22, 2009.
- Accepted April 30, 2009.
- Copyright © 2009 by Cold Spring Harbor Laboratory Press