Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells
- 1Department of Microbial Sciences, School of Biosciences and Medicine, University of Surrey, Guildford GU2 7XH, United Kingdom;
- 2Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA;
- 3Laura and Isaac Perlmutter Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
- Corresponding authors: ian.mohr{at}med.nyu.edu, h.burgess{at}surrey.ac.uk
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↵4 These authors contributed equally to this work.
Abstract
With their categorical requirement for host ribosomes to translate mRNA, viruses provide a wealth of genetically tractable models to investigate how gene expression is remodeled post-transcriptionally by infection-triggered biological stress. By co-opting and subverting cellular pathways that control mRNA decay, modification, and translation, the global landscape of post-transcriptional processes is swiftly reshaped by virus-encoded factors. Concurrent host cell-intrinsic countermeasures likewise conscript post-transcriptional strategies to mobilize critical innate immune defenses. Here we review strategies and mechanisms that control mRNA decay, modification, and translation in animal virus-infected cells. Besides settling infection outcomes, post-transcriptional gene regulation in virus-infected cells epitomizes fundamental physiological stress responses in health and disease.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.349276.121.
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