Acetyl-CoA-directed gene transcription in cancer cells
- Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
- Corresponding author: nav{at}northwestern.edu
Abstract
Fluctuations in acetyl-coenzyme A (acetyl-CoA) levels have been previously associated with changes in global histone acetylation and gene expression. The study by Lee and colleagues (pp. 497–511) in this issue of Genes & Development demonstrates that acetyl-CoA can promote the up-regulation of cell migration- and adhesion-related genes in glioblastoma by controlling Ca2+–NFAT (nuclear factor of activated T cells) signaling.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.315168.118.
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