Fibroblast growth factor signaling in skeletal development and disease
- 1Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA;
- 2UMR-1132, Institut National de la Santé et de la Recherche Médicale, Hopital Lariboisiere, 75475 Paris Cedex 10, France;
- 3Université Paris Diderot, Sorbonne Paris Cité, 75475 Paris Cedex 10, France
- Corresponding author: dornitz{at}wustl.edu
Abstract
Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate skeletal development. FGF signaling regulates development of the limb bud and formation of the mesenchymal condensation and has key roles in regulating chondrogenesis, osteogenesis, and bone and mineral homeostasis. This review updates our review on FGFs in skeletal development published in Genes & Development in 2002, examines progress made on understanding the functions of the FGF signaling pathway during critical stages of skeletogenesis, and explores the mechanisms by which mutations in FGF signaling molecules cause skeletal malformations in humans. Links between FGF signaling pathways and other interacting pathways that are critical for skeletal development and could be exploited to treat genetic diseases and repair bone are also explored.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.266551.115.
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