Return to youth with Sox17
- Akanksha Chhabra1,2 and
- Hanna K.A. Mikkola1,2,3,4,5,6
- 1Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA;
- 2Department of Molecular Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, California 90095, USA;
- 3Department of Microbiology, Immunology and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095, USA;
- 4Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California at Los Angeles, Los Angeles, California 90095, USA;
- 5Jonsson Comprehensive Cancer Center University of California at Los Angeles, Los Angeles, California 90095, USA
Abstract
Maturation of hematopoietic stem cells (HSCs) from fetal to adult state and differentiation to progenitors are thought to follow a one-way street. In this issue of Genes & Development, He and colleagues (pp. 1613–1627) show that overexpression of Sox17 can convert adult multipotential progenitors to self-renewing HSCs that possess fetal properties. These findings challenge the irreversibility of hematopoietic development, and open up new perspectives to understand the different forms of HSC self-renewal at distinct stages of ontogeny and during transformation.
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↵6 Corresponding author.
E-mail hmikkola{at}mcdb.ucla.edu.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.17328611.
- Copyright © 2011 by Cold Spring Harbor Laboratory Press
