Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis

John M. Perry; Linheng Li

doi:10.1101/gad.1670708

Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis

John M. Perry1 and
Linheng Li1,2,3

¹ Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA;
² Department of Pathology, Kansas University Medical Center, Kansas City, Kansas 66160, USA

Abstract

Recent reports have demonstrated that specific tumor suppressors are important for both maintaining hematopoietic stem cell (HSC) quiescence and preventing leukemia development, suggesting a connection between these two activities. Matsuoka and colleagues (pp. 986–991) have further illustrated this theme by demonstrating that inactivation of the tumor suppressor Fbxw7 leads to HSC depletion by active cell cycling and the initiation of leukemia.

Keywords

Footnotes

↵3 Corresponding author.

↵3 E-MAIL lil{at}stowers-institute.org; FAX (816) 926-2023.
Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1670708.