Regulation of mRNA Translation by Signaling Pathways
- 1Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada
- 2Molecular Biology Program, Université de Montréal, Montréal, Québec H3C 3J7, Canada
- 3Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Montréal, Québec H3C 3J7, Canada
- 4Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal, Québec H3T 1E2, Canada
- 5Department of Oncology, McGill University, Montréal, Québec H3T 1E2, Canada
- Correspondence: philippe.roux{at}umontreal.ca; ivan.topisirovic{at}mcgill.ca
Abstract
mRNA translation is the most energy consuming process in the cell. In addition, it plays a pivotal role in the control of gene expression and is therefore tightly regulated. In response to various extracellular stimuli and intracellular cues, signaling pathways induce quantitative and qualitative changes in mRNA translation by modulating the phosphorylation status and thus the activity of components of the translational machinery. In this work we focus on the phosphoinositide 3-kinase (PI3K)/AKT and the mitogen-activated protein kinase (MAPK) pathways, as they are strongly implicated in the regulation of translation in homeostasis, whereas their malfunction has been linked to aberrant translation in human diseases, including cancer.
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