The FHA Domain, a Phosphoamino Acid Binding Domain Involved in the DNA Damage Response Pathway
- M. HUANG and
- S.J. ELLEDGE
This extract was created in the absence of an abstract.
Excerpt
The accurate replication and precise segregation of allchromosomes of a genome are essential for survival of acell. Cells have evolved complex surveillance mechanisms to ensure the faithful transmission of genetic information. These mechanisms are critical not only for monitoring the progression of the normal cell cycle, but alsofor cellular survival in response to DNA damage(Hartwell and Weinert 1989; Elledge 1996). The DNAdamage response pathway consists of multiple branchesthat include cell cycle arrest (the checkpoint), transcriptional regulation, DNA damage repair, and cell death.The function of this pathway is to ensure that DNA lesions are repaired efficiently...
