Some Facts and Thoughts on Cell Cycle Control in Yeast
- K. Nasmyth,
- L. Dirick,
- U. Surana,
- A. Amon, and
- F. Cvrckova
This extract was created in the absence of an abstract.
Excerpt
The passage of cells through the cell cycle can be regulated either by decisions made in G1 to enter S phase or by decisions made in G2 to enter mitosis. Good examples of both types of controls can be found in the life cycles of two very different ascomycete yeasts whose cell cycles have been extensively studied by genetic means: the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe.
Haploid G1 cells of S. cerevisiae have three possible developmental fates: to enter a quiescent state, to differentiate into a gamete capable of conjugation, or to undergo cell division, the choice of which is influenced by environmental conditions (for review, see Pringle and Hartwell 1981; Cross et al. 1988). At a point in their progression through G1 phase called START, the developmental fate of a yeast cell becomes restricted to cell division. Once past START, cells are committed to...
