Response and Binding Elements for Ligand-dependent Positive Transcription Factors Integrate Positive and Negative Regulation of Gene Expression
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Excerpt
Accurate, regulated initiation of mRNA transcription by RNA polymerase II is dependent on the actions of a variety of positive and negative trans-acting factors that bind cis-acting promoter and enhancer elements (Serfling et al. 1985; Echols 1986; McKnight and Tjian 1986; Ptashne 1986; Struhl 1987). These transcription factors may exert their actions in a tissue-specific manner (see, e.g., Walker et al 1983; Ott et al. 1984; Wright et al. 1984; Ornitz et al. 1985; Hammer et al. 1987; Nelson et al. 1988) or function under control of plasma membrane or intracellular ligand-dependent receptors. A major goal in our laboratory has been to identify the molecular mechanisms responsible for the serial activation of hormone-encoding genes in the pituitary during development and the positive and negative regulation of their transcription.
The anterior pituitary gland, which is derived from a common primordium originating in Rathke's pouch, contains phenotypically distinct cell types, each of...
