Colocalization of the myc Oncogene Protein and Small Nuclear Ribonucleoprotein Particles
This extract was created in the absence of an abstract.
Excerpt
Of the 40 or more cellular and viral oncogenes heretofore identified, a subset encodes proteins that reside in the cell nucleus (myc, myb, fos, ski, E1a, p53, polyoma large T, SV40 large T). With the possible exceptions of fos and ski, these proteins have been classified as having an immortalizing activity, based upon their ability to rescue primary cells from senescence without concurrent tumorigenicity (Houweling et al. 1980; Ras-soulzadegan et al. 1983; Jenkins et al. 1984; Mougneau et al. 1984) and on their ability to cooperate with an activated ras gene in the transformation of primary cells (Rassoulzadegan et al. 1982; Land et al. 1983; Ruley 1983; Eliyahu et al. 1984; Parada et al. 1984). A role for the c-myc protein in neoplastic development has been suggested due to alterations in the c-myc proto-oncogene, whether by translocation, amplification, mutation, or retroviral enhancer insertion. Over-expression of c-myc is associated with many...
