Assignment of the GM-CSF, CSF-1, and FMS Genes to Human Chromosome 5 Provides Evidence for Linkage of a Family of Genes Regulating Hematopoiesis and for Their Involvement in the Deletion (5q) in Myeloid Disorders
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Excerpt
Colony stimulating factors (CSFs) are a family of glycoproteins that are believed to be required for growth and maturation of myeloid progenitor cells in vivo (Metcalf 1977, 1984, 1985; Nicola and Vadas 1984; Golde and Takaku 1985). The various CSFs were identified initially by their ability to stimulate progenitor cells to form colonies in semisolid agar; CSFs are classified according to the types of mature blood cells found in the resulting colonies. For example, in the murine system, multi-CSF (IL-3) stimulates the progenitor cells of most of the hematopoietic cell lineages (Ihle et al. 1982), whereas GM-CSF stimulates the proliferation of cells from the granulocyte (G), granulocyte-macrophage (GM), and macrophage (M) lineages (Burgess et al. 1977). M-CSF (CSF-1) (Stanley 1979) and G-CSF (Nicola et al. 1983) primarily stimulate cells committed to the macrophage and granulocyte lineages, respectively. In addition to their ability to stimulate the proliferation of progenitor cells, the...
