Protein Kinases in Cellular Signal Transduction: Tyrosine Kinase Growth Factor Receptors and Protein Kinase C
This extract was created in the absence of an abstract.
Excerpt
Interaction between cells is an essential component of highly differentiated multicellular biological systems. Secreted polypeptide hormones and specific receptor molecules present on the surfaces of target cells represent key components in this communication network. The interaction of hormones such as insulin, insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and colony stimulating factor 1 (CSF-1) with the extracellular portions of their cell-surface receptors triggers a distinct cellular response, which may differ depending on the type and developmental stage of the target cell (Carpenter 1981; Kahn 1985). We have undertaken a molecular biological approach as a first step toward unraveling the cytoplasmic and nuclear events that are initiated by extracellular complex formation between ligands and their respective cell-surface receptors. We have characterized the primary sequences of several receptors, hoping to obtain clues regarding the overall domain structure of these cell-surface molecules and their possible involvement in...
