Hominoid Evolution Based on the Structures of Immunoglobulin Epsilon and Alpha Genes
This extract was created in the absence of an abstract.
Excerpt
The organization of the heavy-chain constant (CH) region genes of the human immunoglobulin (Ig) is 5′-Cµ-Cδ-Cγ3-Cγ1-Cε2-Cα1....ΨCγ....Cγ2-Cγ4-Cε1-Cα2-3′, located on chromosome 14 (Ellison and Hood 1982; Flanagan and Rabbitts 1982; Krawinkel and Rabbitts 1982; Lefranc et al. 1982; Max et al. 1982; Nishida et al. 1982; Takahashi et al. 1982; Bech-Hansen et al. 1983; Hisajima et al. 1983; Flanagan et al. 1984; Migone et al. 1984). In addition to this cluster, the human genome contains a processed Cα pseudogene (Cα3) on chromosome 9 (Battey et al. 1982; Ueda et al. 1982). The human Ig Cα gene family thus consists of lists of three members: the Cα1 gene (active), the Cα2 gene (truncated pseudogene), and the Cα3 gene (processed pseudogene). Since mouse contains only one Cα gene (Shimizu et al. 1982), creation of two Cα pseudogenes in the human genome seems to have taken place after mammalian radiation. Using the human Cα probe...
