Are Lysosomes a Site of Enveloped-virus Penetration?
This extract was created in the absence of an abstract.
Excerpt
At the Cold Spring Harbor Symposium in 1962 concerning animal virus biology, one of the hotly debated topics was whether animal viruses enter their host cells through the plasma membrane or whether they are introduced by endocytosis prior to membrane penetration. Although it has since become possible to characterize the later stages of the replication cycle of many viruses in remarkable detail, the early interactions between virus and cell still remain a puzzle. Even in the best-characterized virus systems it is not known exactly how the viral genome is transported into the cytoplasm or the nucleus for infection (Dales 1973; Lonberg-Holm and Philipson 1974).
In the case of enveloped animal viruses, two alternative pathways into the cell are generally considered. One is the fusion of the viral membrane with the plasma membrane of the host cell. Such a reaction, well known for the paramyxoviruses, results in the introduction of the...
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↵* Present address: Section of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510
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↵† Present address: Division of Membrane Biology and Biochemistry, Institute of Experimental Pathology, German Cancer Research Centre, 6900 Heidelberg, Federal Republic of Germany.
