DNA Binding and Sedimentation Properties of SV40 T Antigens Synthesized In Vivo and In Vitro
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Excerpt
SV40 large and small T antigens have been shown to have essential and independent roles in virus-induced transformation. Large T antigen has a role in viral DNA replication (Tegtmeyer 1972), L-strand mRNA transcription (Cowan et al., 1973), E-strand mRNA autoregulation (Reed et al. 1976), and initiation and maintenance of the transformed state (Kimura and Dulbecco 1973; Martin and Chou 1975; Tegtmeyer 1975; Brugge and Butel 1975; Osborn and Weber 1975b). Small T antigen does not appear to have an obvious role in the lytic cycle of the virus (Shenk et al. 1976) but, depending on the assay (Bouck et al. 1978; Sleigh et al. 1978; Feunteun et al. 1978; Martin et al. 1979), is involved in the viral transformation process. As most of the large T antigen's lytic roles imply its interaction with DNA, it is not unreasonable to assume that some of its part in transformation may also be...
