SOME PROBLEMS OF NEURO-MUSCULAR TRANSMISSION
This extract was created in the absence of an abstract.
Excerpt
It is impossible to try and state the problems of nerve-muscle transmission without immediately treading on controversial ground. There are physiologists who would even deny that a separate problem of transmission across nerve-muscle, or other synapses, exists distinct from the mechanism of unicellular propagation of impulses. There are others who feel that the evidence for such a distinction is altogether overwhelming, and that at the myoneural junction a highly specific chemical process is involved, in which acetylcholine (Ach.) is released from the motor nerve endings and reacts with chemoreceptor molecules in the muscular, end-plate surface so as to depolarize the muscle fibre and initiate a new wave of unicellular propagation. Some experiments will be reported here, in which this view has been used as an operational base and whose object it was to find out more about the mechanisms by which Ach. is released from active nerve terminals and then...
