Chromosome 21 and Down Syndrome: The Post-Sequence Era
This extract was created in the absence of an abstract.
Excerpt
Trisomy 21, the etiology of Down syndrome (DS), isthe most common cause of genetic mental retardation,and a model for the numerous aneuploidy syndromes. DSwas first described by John Langdon Down in 1866(Down 1866), and the trisomy for a group G acrocentricchromosome was recognized by Lejeune et al. in 1959(Lejeune et al. 1959). Many recent studies have used human chromosome 21 as a model for genomic studies suchas determination of haplotype block (Patil et al. 2001),identification of transcribed sequences (Kapranov et al.2002), and comparative genomics (Frazer et al. 2003)...
