Mammalian Homeo Box Genes
This extract was created in the absence of an abstract.
Excerpt
Drosophila homeo box sequences are 180-bp exonic elements residing within genes involved in the determination of body segment number and identity. These genes include members of the Antennapedia and bithorax complexes as well as others involved in Drosophila morphogenesis, such as engrailed (Laughon and Scott 1984; McGinnis et al. 1984b,c; Scott and Weiner 1984; Fjose et al. 1985; Poole et al. 1985). The functions of the homeo box sequences themselves are not yet known. It has been established that they exist in open reading frames and that they are located in genes whose protein products are nuclear in location in the few instances examined (White and Wilcox 1984; Beachy et al. 1985; Scott et al., this volume). Deduced amino acid sequences indicate a high level of conservation between organisms as distantly related as Drosophila and man (Levine et al. 1984; McGinnis et al. 1984a; Colberg-Poley et al. 1985), high levels...
