Structural Studies of H-2 and TL Alloantigens
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Excerpt
Several products of chromosome 17 in the mouse have been shown to have similar subunit structures, namely, a large chain of approximately 44,000 m.w. and a small chain of about 12,000 m.w. These include H-2D, H-2K (Nathenson and Cullen 1974; Rask et al. 1974; Natori et al. 1974; Silver and Hood 1974; Vitetta et al. 1975; Östberg et al. 1975b), and thymus leukemia (TL) antigen (Vitetta et al. 1975; Östberg et al. 1975a,b; Stanton et al. 1975; Anundi et al. 1975), whose gene maps to the right of H-2D.
In this paper, we attempt to answer several questions concerning the structure of both subunits: (1) Is the small subunit (β2-microglobulin [β2m] in the case of H-2 and TL) associated only with H-2 and TL antigens on the cell surface, or does β2m exist in the “free” form and/or associated with many other molecules? If there is a large excess of...
