Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons

  1. Inna Dubchak1,
  2. Michael Brudno1,
  3. Gabriela G. Loots2,
  4. Lior Pachter3,
  5. Chris Mayor1,
  6. Edward M. Rubin2, and
  7. Kelly A. Frazer2,4,5
  1. 1Center for Bioinformatics and Computational Genomics, 2Genome Sciences Department, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA; 3Department of Mathematics, University of California at Berkeley, Berkeley, California 94720, USA

Abstract

Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human–mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.

[The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF276990.]

Footnotes

  • ↵4 Present address: Affymetrix, Santa Clara, California 95051 USA.

  • ↵5 Corresponding author.

  • E-MAIL kelly_frazer{at}affymetrix.com; FAX (408) 481-0422.

  • Article and publication are at www.genome.org/cgi/doi/10.1101/gr.142200.

    • Received March 28, 2000.
    • Accepted July 12, 2000.
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  1. doi: 10.1101/gr.142200 Genome Res. 10: 1304-1306 Cold Spring Harbor Laboratory Press

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