Analysis of the Mouse Transcriptome for Genes Involved in the Function of the Nervous System

  1. Stefano Gustincich1,13,14,
  2. Serge Batalov2,
  3. Kirk W. Beisel3,
  4. Hidemasa Bono4,
  5. Piero Carninci4,5,
  6. Colin F. Fletcher2,6,
  7. Sean Grimmond7,
  8. Nobutaka Hirokawa8,
  9. Erich D. Jarvis9,
  10. Tim Jegla2,
  11. Yuka Kawasawa10,
  12. Julianna LeMieux1,
  13. Harukata Miki8,
  14. Elio Raviola1,
  15. Rohan D. Teasdale7,
  16. Naoko Tominaga4,
  17. Ken Yagi4,
  18. Andreas Zimmer11,
  19. RIKEN GER Group4,
  20. GSL Members5,12,
  21. Yoshihide Hayashizaki4,5, and
  22. Yasushi Okazaki4,5
  1. 1Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
  2. 2Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, USA
  3. 3Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
  4. 4Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan
  5. 5Genome Science Laboratory, RIKEN, Hireosawa, Wako, Saitama, 351-0198, Japan
  6. 6The Scripps Research Institute, La Jolla, California 92037, USA
  7. 7Institute for Molecule Bioscience and ARC Special Research Centre for Functional and Applied Genomics, University of Queensland, Q4072, Australia
  8. 8Graduate School of Medicine, University of Tokyo, Tokyo, 113-0033, Japan
  9. 9Duke University Medical Center, Department of Neurobiology, Durham, North Carolina 27710, USA
  10. 10Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
  11. 11Department of Psychiatry, University of Bonn, Bonn 53105, Germany

Abstract

We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function.We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins.We also identified previously unknown candidates for secreted neuroactive molecules.The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored.A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.

Footnotes

  • [Supplemental material is available online at www.genome.org.]

  • Article and publication are at http://www.genome.org/cgi/doi/10.1101/gr.1135303.

  • ↵13 Present address: Laboratory of Molecular Neurobiology, International School for Advanced Studies S.I.S.S.A., Area Science Park, Trieste, Italy.

  • ↵14 Corresponding author. E-MAIL gustinci{at}sissa.it; FAX 39 (040) 375-6502.

  • ↵12 Takahiro Arakawa,4 Kazunori Waki,4 and Jun Kawai4,5

    • Accepted April 16, 2003.
    • Received December 30, 2002.
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  1. doi: 10.1101/gr.1135303 Genome Res. 13: 1395-1401 Cold Spring Harbor Laboratory Press

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