Corrigendum: TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency
This extract was created in the absence of an abstract.
Genes & Development 32: 1161–1174 (2018)
We have discovered two errors in our published paper noted above. These errors, which were entirely textual, occurred in the Introduction and Discussion and in no way affect the results or conclusions of our study. We have corrected the errors as follows, and the updated version of our paper has replaced the previous version online.
First, we mistakenly incorporated two sentences in the first paragraph of the Introduction from an article by Venables et al. (2013). These two sentences have been deleted: “For example, different isoforms of Foxp1 produced from ESC-specific AS have differential effects on the induction of key pluripotency genes such as OCT4 and NANOG (Gabut et al. 2011). Similarly, alternative splice forms of DNMT3B are specific to stem cells, implying that layered and integrated regulation of gene expression occurs at the levels of transcription and splicing (Gopalakrishna-Pillai and Iverson 2011).” This text has been replaced as follows: “For example, different isoforms of Foxp1 and Oct4, which are important transcription factors that function in determining stem cell identities, are produced by ESC-specific AS, and this controls their transcriptional activities and targets (Atlasi et al. 2008; Gabut et al. 2011). Similarly, isoforms of DNMT3B produced by AS are also known to be specific for stem cells, suggesting that AS regulation contributes to maintaining a stem cell-specific epigenetic state in ESCs (Gopalakrishna-Pillai and Iverson 2011; Liao et al. 2015).”
We sincerely apologize for this to both the authors of the previous paper and the readers of our article.
Second, in our study, we identified human embryonic stem cell (hESC)-specific alternative splicing (AS) regulation of transcripts encoded by the TCF3 gene (also known as E2A) and established its functional significance during hESC differentiation. However, we were recently made aware that we had in some instances …
