Liberating cohesin from cohesion
- Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
- Corresponding author: kerry_bloom{at}unc.edu
Abstract
Cohesin was identified through its major role in holding sister chromatids together. We are learning through analysis of cohesin and other members of the protein family (SMC [structural maintenance of chromosomes]) and their regulators that these ring complexes contribute to chromosome organization and dynamics throughout the cell cycle. We need to consider not only how ring complexes are regulated but how they interact with their fluctuating chromatin substrate.
Keywords
- cohesin acetyltransferases
- ESCO1/2
- centromere
- chromatin territories
- chromosome segregation
- sister chromatid cohesion
Footnotes
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.309732.117.
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