‘Cold cuts’ added to the circadian smorgasbord of regulatory mechanisms
- Corresponding author: carla.green{at}utsouthwestern.edu
Abstract
In mammals, rhythms in body temperature help to entrain and synchronize circadian rhythms throughout the organism, and the cold-inducible RNA-binding protein (CIRBP) is one of the mediators of these daily temperature changes. Cirbp mRNA expression is regulated by the daily subtle rhythms in body temperature, and a new study by Gotic and colleagues (pp. 2005–2017) reveals a surprising and novel mechanism that involves temperature-dependent enhancement of splicing efficiency.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.289587.116.
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