Tyrosyl phosphorylation toggles a Runx1 switch
- 1Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 1L7, Canada;
- 2Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada;
- 3Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Abstract
The Runx1 transcription factor is post-translationally modified by seryl/threonyl phosphorylation, acetylation, and methylation that control its interactions with transcription factor partners and epigenetic coregulators. In this issue of Genes & Development, Huang and colleagues (pp. 1587–1601) describe how the regulation of Runx1 tyrosyl phosphorylation by Src family kinases and the Shp2 phosphatase toggle Runx1's interactions between different coregulatory molecules.
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↵4 Corresponding author
E-mail nancyas{at}exchange.upenn.edu
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.198051.112.
- Copyright © 2012 by Cold Spring Harbor Laboratory Press
