New chaps in the histone chaperone arena
- Department of Biochemistry, Howard Hughes Medical Institute, New York University School of Medicine, New York 10016, USA
Abstract
Understanding exactly how chromatin is assembled is paramount to addressing how select histone modifications may be transmitted, a putative epigenetic process. In the June 15, 2010, issue of Genes & Development, Drané and colleagues (pp. 1253–1265) identified DAXX as a novel H3.3-specific chaperone. This finding, in the context of others published by Goldberg and colleauges in Cell and Sawatsubashi and colleagues (pp. 159–170) in the January 15, 2010, issue of Genes & Development, provides the impetus for uncovering the mechanistic and functional properties of alternative histone deposition pathways.
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↵1 Corresponding author.
E-MAIL reinbd01{at}nyumc.org; FAX (212) 263-9040.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1946810.
- Copyright © 2010 by Cold Spring Harbor Laboratory Press
